Surp and g-patch domain-containing protein 101

Protein analysis mass spectrometry protein expression protein interactions protein purification. Protein topology is represented by contact and orientation of secondary structure elements sses. Two additional proteins containing surp domains were found by coip table 1, the u2 snrnpassociated surp motifcontaining protein u2surpsr140 and the a complex component surp and gpatch domaincontaining protein 1 sugp1sf4. Putative splicing factor, arginineserinerich 14 is a protein that in humans is encoded by the. Sugp1 surp and gpatch domaincontaining protein 1 mus. We identified the proteins by mass spectrometry and found that levels of the spliceosomal protein sugp1 surp and gpatch domain containing 1 were greatly reduced in the mutant sf3b1 spliceosome.

Geneloc map region for chromosome 19 20,783,592 24,784,768 bp around gh19j022783 genes enhancers. Surp domains interact with sf1, and gpatch domains were shown to activate rna. Loom is an up to date snap view of the microrna literature landscape. Sugp1 surp and gpatch domaincontaining protein 1 homo. Loom reads relevant scientific publications that mention human specific micrornas, extract the relevant parts, and then scores the relationship between the microrna and the specific gene or disease being studied. Sugp1, surp and gpatch domain containing 1 vertebrate orthologs 10 human ortholog sugp1, surp and gpatch domain containing 1. This database of renal inner medullary collecting duct imcd proteins is based on published protein mass spectrometry data from the nhlbi epithelial systems biology laboratory. Gtex compendium human tissue compendium novartis global cancer map broad institute nci60 cell lines national cancer institute.

Surp and gpatch domaincontaining protein 1like protein. Sampson and hewitt 2003 also cloned the mouse orthologs. A short, evolutionarily conserved region of sf1 interacts with the surp domains, stressing their role in protein protein interactions. Aggf1, angiogenic factor with g patch and fha domains 1. An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by western blot with a specific polyclonal antibody or second epitope tag. Several groups of gpatch containing proteins are conserved in animals, plants and fungi. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. The rna molecules stored are stalled translation preinitiation complexes.

Only three common genes were found to be downregulated in all comparisons plectin domain containing protein, plec, tetratricopeptide. Heat shock 70 kda protein 8 also known as heat shock cognate 71 kda protein or hsc70 or hsp73 is a heat shock protein that in humans is encoded by the hspa8 gene on chromosome 11. Stress granules are 100200 nm in size when biochemically purified, not surrounded by membrane, and associated with the endoplasmatic reticulum. Surp and gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14, splicing factor, arginineserinerich 14. Loc1982691 surp and gpatch domaincontaining protein 1. Diseases associated with sugp1 include louping ill and osteogenesis imperfecta, type i. Gabpa, ga binding protein transcription factor, alpha subunit 60kda. Fullkh domaincontaining, rnabinding, signal transductionassociated protein 2. Atlas of genetics and cytogenetics in oncology and haematology home genes leukemias solid tumors cancerprone deep insight case reports journals portal teaching.

Both sf4 and sfrs14 contain 2 surp motifs and a single gpatch domain in their c termini. Pdf mammalian splicing factor sf1 interacts with surp. Comprehensive transcriptomic analysis of the process of gonadal sex. A domain found in a protein subunit of human rnase mrp and rnase p ribonucleoprotein complexes and archaeal proteins. Gene ontology go annotations related to this gene include nucleic acid binding and rna binding. Loc1982691 surp and gpatch domaincontaining protein 1like wiretailed manakin gene id. Comprehensive transcriptomic analysis of the process of. Diseasecausing mutations in sf3b1 alter splicing by.

Pdf on jan 1, 2020, mat jusoh and others published ijhoscr. Among its related pathways are mrna splicing major pathway. Yeast twohybrid screens identified two surp domaincontaining u2 snrnp proteins as partners of sf1. Atrich interactive domaincontaining protein 1a 3312 hspa8 heat shock cognate 71 kda protein 9919 sec16a 20 1. Sugp1 surp and gpatch domain containing 1 is a protein coding gene. We used affinity purification to isolate spliceosomal complexes associated with either wildtype wt or the hotspot k700e mutant sf3b1. We can not exclude the possibility that gpkow also binds dna in addition to rna since other gpatch domain containing proteins have been shown to be involved in dna repair and telomere.

Sugp2 surp and gpatch domain containing 2 is a protein coding gene. At1g04910 coatomer, beta subunit at3g15980 pectin lyaselike superfamily protein. The figure on the left represents the contact map with information on type of orientation two sses share color coded. Genes upregulated in pc3 cells prostate cancer after knockdown of ezh2 geneid2146 by rnai. Gpatch domain and kow motifscontaining protein, gpkow. Antig patch domain and kow motifscontaining protein antibody produced in rabbit, antig patch domaincontaining protein 5 antibody produced in rabbit, antiprotein mos2 homolog antibody produced in rabbit, antiprotein t54 antibody produced in rabbit. Alternatively spliced transcript variants have been described. Hect and rld domain containing e3 ubiquitin protein ligase 2. Stress granule wikimili, the best wikipedia reader.

Aliases sugp2, sfrs14, surp and gpatch domain containing 2, srfs14. Physiological substrates of campdependent protein kinase. Sugp2 surp and gpatch domaincontaining protein 2 homo. Rank locus id links locus select coexpressed genes description mutual rank weighted pcc wolf psort kegg pathway transcription factor gene symbol gene name msu id. Sugp1 surp and gpatch domain containing 1, authors. Below is a sorted list of the top 500 accessed transcripts since 722014. Mammalian splicing factor sf1 interacts with surp domains of u2 snrnpassociated proteins. With this, we aim to provide a visually compelling and complete overview of how micrornas relate to specific. Postset cysteinerich motif following a subset of set domains. In some of these proteins the g patch is the only recognisable domain but in most of them it is combined with other domains, which include welldefined rnabinding domains, such as the rrm, dsrbd, surp and r3h. Unbound material was incubated for 1 h at 4c with protein g. Surp and gpatch domaincontaining protein 1, rna binding protein rbp, splicing factor 4. At3g52120 surp and gpatch domaincontaining protein 1.

G patch domaincontaining protein 6,gpatc6,gpatch6,homo sapiens,human,kiaa1847,zc3h9,zc3hdc9,zgpat,zinc finger and g patch domaincontaining protein,zinc finger ccch domaincontaining protein 9,zinc f. Mammalian splicing factor sf1 interacts with surp domains. Ezh2 is a polycomb group pcg protein that promotes the latestage development of cancer by silencing a specific set of genes, at least in part through trimethylation of. Ipr040169 surp and gpatch domaincontaining protein 12. In particular, many isoforms containing alternative exons are expressed in. Ezh2 is a polycomb group pcg protein that promotes the latestage development of cancer by silencing a specific set of genes, at least in part. Complete information for sugp1 gene protein coding, surp and gpatch domain containing 1, including. Among its related pathways are gene expression and mrna splicing major pathway. Sugp2 ensg00000064607, surp and gpatch domain containing 2. Surp and gpatch domaincontaining protein 1, rnabinding protein rbp, splicing factor 4.